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Updated: Jul 13, 2026

Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents
Published on: May 28, 2014
Insight into the reactive form of the anticancer agent iproplatin
Erika Volckova1, Evelyne Weaver, Rathindra N Bose
1Michael Faraday Laboratory, Department of Chemistry and Biochemistry, Northern Illinois University, DeKalb, IL 60115, United States.
Abstract:
The reaction of iproplatin with reduced glutathione at different mole ratios yielded cis-di(isopropylamine)chloro-glutathionatoplatinum(II), not the expected cis-dichloro- species, indicating a mode of action of this anticancer agent that is different from that of cis-diamminedichloroplatinum(II).
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