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Endobronchial Ultrasound-guided Intratumoral Injection of Cisplatin for the Treatment of Isolated Mediastinal Recurrence of Lung Cancer

Endobronchial Ultrasound-guided Intratumoral Injection of Cisplatin for the Treatment of Isolated Mediastinal Recurrence of Lung Cancer

Published on: February 12, 2017

Primary lung cancer and extrapulmonary malignancy.

Hans-Stefan Hofmann¹, Heinz Neef, Peter Schmidt

¹Department of Cardio-Thoracic Surgery, Martin Luther University Halle-Wittenberg, Ernst-Grube-Street 40, 06096 Halle, Germany. stefan.hofmann@medizin.uni-halle.de

European Journal of Cardio-Thoracic Surgery : Official Journal of the European Association for Cardio-Thoracic Surgery

|August 21, 2007

Summary

This summary is machine-generated.

Second primary lung cancer (SPLC) incidence is rising. Curative treatment, especially standard resection, offers the best prognosis for SPLC patients, highlighting the need for early detection and prompt oncological care.

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Endobronchial Ultrasound-guided Intratumoral Injection of Cisplatin for the Treatment of Isolated Mediastinal Recurrence of Lung Cancer

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Published on: February 12, 2017

Next Generation Sequencing for the Detection of Actionable Mutations in Solid and Liquid Tumors

Next Generation Sequencing for the Detection of Actionable Mutations in Solid and Liquid Tumors

Published on: September 20, 2016

Area of Science:

Oncology
Epidemiology
Thoracic Surgery

Background:

Increasing incidence of second primary malignancies necessitates understanding of second primary lung cancer (SPLC).
Extrapulmonary malignancies precede the development of SPLC in affected patients.

Purpose of the Study:

To investigate the incidence, treatment strategies, and patient outcomes for second primary lung cancer (SPLC).
To identify prognostic factors influencing survival in SPLC patients.

Main Methods:

Retrospective analysis of 163 SPLC patients diagnosed between 1996 and 2005.
Patients were categorized by treatment intent: curative (n=59), palliative (n=76), or best supportive care (n=28).
Statistical analyses included univariate and multivariate Cox proportional hazards models.

Main Results:

The incidence of SPLC was determined to be 1.6 per 100,000 inhabitants.
The overall 5-year survival rate was 12.7% (median survival 11.4 months).
Curative treatment significantly improved prognosis (median survival 31.0 months); TNM staging was the sole independent predictor of survival.

Conclusions:

Standard resection is recommended as the surgical method of choice for operable SPLC due to superior survival rates.
The findings underscore the importance of robust oncological care systems for early SPLC detection in patients with prior malignancies.