[Stimulating effect of long-term low-dose radiation on granulocytopoiesis]

A mathematical model simulating variations in granulocytopoiesis of mammals exposed to chronic irradiation has been built. The model has been developed to take into account the chalone mechanism of hemopoiesis regulation. The model represents a system of 12 nonlinear differential equations. The modelling results have been found to be in agreement with experimental observations of variations in granulocytopoiesis of rats within a wide range of radiation dose rates. This model has been used for the first time to simulate a stimulating effect of prolonged irradiation with a low dose rate on granulocytopoiesis. Manifestations of this effect are explained. This model can be used to predict the effect of prolonged irradiation with different dose rates on variations of granulocytopoiesis in mammals.