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Consequences of poor compliance with bisphosphonates
Becky A Briesacher1, Susan E Andrade, Robert A Yood
1University of Massachusetts Medical School, Division of Geriatric Medicine, Biotech Four, Worcester, MA 01605, USA. becky.briesacher@umassmed.edu
Bone
|August 21, 2007
Summary
Bisphosphonate adherence is key for preventing osteoporotic fractures and reducing healthcare costs. Even moderate compliance (40-60%) shows benefits, but many patients fail to achieve these levels.
Area of Science:
- Pharmacoeconomics
- Geriatric Medicine
- Bone Health
Background:
- Clinical trials show bisphosphonates prevent fractures and reduce healthcare costs.
- Real-world data on bisphosphonate compliance and its impact are limited.
Purpose of the Study:
- To assess osteoporotic fracture rates and healthcare utilization based on bisphosphonate compliance in clinical practice.
- To evaluate the relationship between medication adherence and health outcomes.
Main Methods:
- Retrospective cohort study using pharmacy and medical claims data (2000-2004).
- Included osteoporosis patients (≥40 years) initiating alendronate or risedronate.
- Measured medication compliance, fracture rates, and healthcare costs.
Main Results:
- Low compliance (0-39%) was observed in 34-52% of patients.
- Fracture risk reduction benefits were seen with compliance levels of at least 40-60%.
- High to moderate compliance ($>$40%) yielded significant annual healthcare cost savings ($366-$859).
Conclusions:
- Bisphosphonate compliance of 40-60% can reduce fracture risk and healthcare costs.
- A significant proportion of patients do not achieve minimal compliance levels for therapeutic benefits.
- Optimizing adherence is crucial for realizing the full potential of bisphosphonate therapy.
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