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Updated: Jul 13, 2026

A Nonsequencing Approach for the Rapid Detection of RNA Editing
Published on: April 21, 2022
A hypothesis on the identification of the editing enzyme in plant organelles
Véronique Salone1, Mareike Rüdinger, Monika Polsakiewicz
1URGV, 2 Rue Gaston Crémieux, F-91057 Evry Cedex, France.
Abstract:
RNA editing in plant organelles is an enigmatic process leading to conversion of cytidines into uridines. Editing specificity is determined by proteins; both those known so far are pentatricopeptide repeat (PPR) proteins. The enzyme catalysing RNA editing in plants is still totally unknown. We propose that the DYW domain found in many higher plant PPR proteins is the missing catalytic domain. This hypothesis is based on two compelling observations: (i) the DYW domain contains invariant residues that match the active site of cytidine deaminases; (ii) the phylogenetic distribution of the DYW domain is strictly correlated with RNA editing.
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