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[Adenylate cyclase/Lipase. Hormone receptor induction].
Biochimie
|November 1, 1975
Summary
Brown adipose tissue (BAT) in guinea pigs shows increased adenylate cyclase activity (AC) during development. Norepinephrine stimulates AC and lipolysis after birth, crucial for neonatal thermogenesis.
Area of Science:
- Biochemistry
- Physiology
- Developmental Biology
Context:
- Brown adipose tissue (BAT) is crucial for non-shivering thermogenesis.
- Understanding the enzymatic regulation of BAT activity during development is key to neonatal survival.
Purpose:
- To investigate the developmental changes in adenylate cyclase (AC) activity and lipolytic response to norepinephrine in guinea pig BAT.
- To elucidate the role of the AC/lipase system in neonatal thermogenesis.
Summary:
- Adenylate cyclase (AC) activity was detected in guinea pig brown adipose tissue (BAT), increasing during development and peaking at late gestation.
- Norepinephrine stimulated AC activity at the end of gestation, but this effect diminished postnatally.
- Basal lipolytic activity in BAT increased significantly around day 15 postpartum, with potent activation by norepinephrine observed only after birth.
- The correlation between AC and lipase activity suggests their involvement in neonatal thermogenesis via the AC/lipase system.
Impact:
- This study highlights the developmental regulation of BAT enzymatic activity in guinea pigs.
- The findings provide insights into the physiological mechanisms underlying neonatal thermogenesis and the role of the AC/lipase system.