Related Experiment Video
Updated: Jul 13, 2026
09:41
Comprehensive Autopsy Program for Individuals with Multiple Sclerosis
Published on: July 19, 2019
Multiple auras: clinical significance and pathophysiology.
P Widdess-Walsh1, P Kotagal, L Jeha
1Cleveland Clinic Epilepsy Center, Cleveland Clinic, Cleveland, OH 44195, USA.
Neurology
|August 22, 2007
Summary
Patients experiencing multiple seizure auras often have epilepsy in the right hemisphere. These individuals may benefit from epilepsy surgery, suggesting a localized seizure origin.
Area of Science:
- Neurology
- Epileptology
- Clinical Neuroscience
Background:
- Partial epilepsy can manifest with diverse aura types.
- The clinical significance of multiple auras in a single patient remains unclear.
Purpose of the Study:
- To investigate the clinical and electrophysiologic features of patients reporting multiple aura types.
Main Methods:
- Retrospective study of patients evaluated between 1989-2005.
- Analysis of clinical data, electroencephalography (EEG), and ictal single-photon emission computed tomography (SPECT).
Main Results:
- Thirty-one patients reported multiple aura types.
- Most patients with multiple auras (90% with ≥2 types, 100% with ≥3 types) had seizures originating from the right/nondominant hemisphere.
- Epilepsy surgery achieved seizure freedom in 53% of patients.
Conclusions:
- Multiple aura types are associated with localized epilepsy in the nondominant hemisphere.
- These patients are often suitable candidates for epilepsy surgery.
- A potential mechanism involves restricted EEG seizure spread activating sequential zones without affecting consciousness.
Related Concept Videos
01:21Aneurysm II: Clinical Manifestations and Diagnostic Studies
Thoracic, aortic arch and abdominal aneurysms are significant vascular conditions that can present with various clinical manifestations and lead to serious complications. Understanding these manifestations and the appropriate diagnostic studies is essential for effective management and treatment.Thoracic Aortic AneurysmsThoracic aortic aneurysms often remain asymptomatic until they reach a size that impinges on adjacent structures. They typically cause deep, diffuse chest pain that radiates to...
01:19Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations
The pathophysiology of Acute Coronary Syndrome [ACD] involves several key processes:The main underlying cause of ACD is atherosclerosis, a chronic inflammatory disease characterized by the buildup of lipid-laden plaques within the coronary arteries.As the atherosclerotic plaque grows in the coronary artery, it may become unstable due to the formation of a lipid-rich core and a thin fibrous cap. Inflammatory cells within the plaque, such as macrophages, secrete enzymes that degrade the...
01:19Multiple Sclerosis l: Introduction
Multiple sclerosis is a chronic autoimmune disease of the central nervous system (CNS) that affects the brain, spinal cord, and optic nerves. It is an inflammatory demyelinating disorder and a leading cause of neurological disability in young adults.EpidemiologyMS commonly begins between 20 and 40 years of age and is twice as common in women. Its exact cause remains unclear, but genetic susceptibility contributes, with higher risk in first-degree relatives and identical twins. A greater...
01:22Cerebral Edema ll: Pathophysiology
Vasogenic edema is a major form of cerebral edema characterized by abnormal accumulation of fluid in the brain’s extracellular space due to disruption of the blood–brain barrier (BBB). The BBB is a specialized structure composed of endothelial cells connected by tight junctions, supported by astrocytic endfeet and a basement membrane. Under normal conditions, it tightly regulates the movement of ions, proteins, and solutes between the bloodstream and brain parenchyma. When this barrier loses...
01:22Myasthenia Gravis ll: Pathophysiology
The disease process of myasthenia gravis begins at the neuromuscular junction, where antibodies attack key proteins needed for muscle activation. This immune reaction weakens signal transmission, leading to the characteristic muscle fatigue and weakness that define the condition.Immune-Mediated DamageIn most individuals, antibodies target acetylcholine receptors (AChRs) on the postsynaptic membrane of muscle cells. By blocking acetylcholine binding, these antibodies prevent the nerve signal...
01:26Asthma-II: Pathophysiology and Classification
Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include: