Bidirectional communication: growth and immunity in domestic livestock

Evidence continues to mount supporting the existence of a bidirectional communication network between the immune system and the somatotropic axis in a variety of species. For more than 4 decades, researchers have sought and identified linkages between the growth axis and the immune system. Although significant advances have been made with regard to elucidation of various bidirectional communication pathways between the immune system and growth axis in humans and rodents, the current paper focuses on the relationships between the immune system and somatotropic axis in sheep, cattle, and swine. Aspects from historical and current research associated with changes in somatotropic function following immune challenges with endotoxin, parasites, viruses, and bacteria have been provided. Collectively, these studies demonstrate that a bidirectional communication network, similar to that described in humans and rodents, also exists in a variety of domestic livestock. Identifying and understanding this bidirectional communication network could have significant economic benefits if it leads to intervention strategies to prevent production losses associated with sickness and disease.