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Assays for the Specific Growth Rate and Cell-binding Ability of Rotavirus

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Rotavirus and adenovirus in Rondônia

Gleiciene Félix Magalhães1, Paulo Afonso Nogueira, Andréa Fagundes Grava

  • 1Centro de Pesquisa em Medicina Tropical, Porto Velho, RO, Brasil.

Memorias Do Instituto Oswaldo Cruz
|August 22, 2007
PubMed

Insights

Rotavirus A is a primary cause of viral gastroenteritis in young children in Western Brazilian Amazonia, affecting 23.6% of cases. This study highlights the prevalence of enteric viruses in hospitalized infants and young children.

Area of Science:

  • Pediatrics
  • Virology
  • Public Health

Background:

  • Acute gastroenteritis is a leading global cause of illness, particularly in infants and young children.
  • Viral gastroenteritis poses a significant public health challenge worldwide.
  • Understanding the specific viral agents responsible for gastroenteritis in different regions is crucial for effective management.

Purpose of the Study:

  • To assess the incidence of diarrhea and identify the prevalence of rotavirus and adenovirus in hospitalized children under five years old in Western Brazilian Amazonia.
  • To compare the detection rates of these viruses in diarrheal cases versus a control group.
  • To provide etiological data to aid physicians in diagnosing and treating viral gastroenteritis in this population.

Main Methods:

  • A 24-month prospective study involving 877 hospitalized children under five years old.
  • Inclusion of 470 children with diarrhea and 407 age-matched controls.
  • Antigen detection using enzyme immunoassay (EIA) and latex particle techniques for rotavirus and adenovirus.

Main Results:

  • Rotavirus A was identified as the major causative agent, present in 23.6% of gastroenteritis cases, with 90% occurring in young children.
  • Adenovirus infections were detected in 6.4% of cases.
  • Rotavirus and adenovirus were found in 10.1% and 1.7% of the control group, respectively, with similar Rotavirus A shedding in the youngest controls.

Conclusions:

  • Rotavirus A is a significant cause of viral gastroenteritis in hospitalized children in Western Brazilian Amazonia.
  • The study provides the first evidence of enteric virus presence in the infantile population of this region.
  • Further investigation is needed to determine the etiology of remaining diarrhea cases and explore other enteric viruses.

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