Related Experiment Video
Updated: Jul 12, 2026
09:11
Y-90 Radioembolization and PD-1 Inhibitor as Neoadjuvant Treatment in Hepatocellular Carcinoma
Published on: May 24, 2024
Dose perturbation caused by stents: experiments with a model 90Sr/90Y source.
Krzysztof Wilczek1, Barbara Petelenz, Alicja Strzała
1The Silesian Center for Heart Diseases, 3rd Chair and Clinical Hospital for Heart Diseases, Medical University of Silesia, 41-800 Zabrze, Szpitalna 2, Poland.
Cardiovascular and Interventional Radiology
|August 22, 2007
Summary
Metallic stents significantly alter radiation doses during intravascular brachytherapy for in-stent restenosis. Thick-strut stents cause excessive dose perturbations, making them a contraindication for this treatment.
Area of Science:
- Medical Physics
- Radiation Oncology
- Cardiovascular Interventions
Background:
- Intravascular brachytherapy is used to treat in-stent restenosis.
- Metallic stents can interfere with radiation dose distribution.
- New stent generations necessitate updated understanding of these effects.
Purpose of the Study:
- To investigate the impact of various metallic stents on dose distribution during intravascular brachytherapy.
- To evaluate dose perturbations caused by 14 different stents used in clinical practice.
Main Methods:
- A continuous (90)Sr/(90)Y solution served as the model source.
- Dose distribution was measured in a Plexiglas phantom using GafChromic MD-55-2 film.
- Stent characteristics including mass, strut thickness, and material atomic number were varied.
Main Results:
- Dose reductions near the source (2 mm) ranged from 11% to 47%.
- Stent strut thickness and mesh density were more critical than atomic number in causing dose perturbations.
- No simple correlation was found between all stent characteristics and dose perturbation.
Conclusions:
- Stent characteristics significantly influence intravascular brachytherapy outcomes.
- Thin-strut stents are recommended for patients undergoing this treatment.
- Thick-strut stents present a contraindication due to unpredictable dose perturbations.
