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Related Experiment Video

Updated: Jul 12, 2026

Techniques of Sleeve Gastrectomy and Modified Roux-en-Y Gastric Bypass in Mice

Techniques of Sleeve Gastrectomy and Modified Roux-en-Y Gastric Bypass in Mice

Published on: March 20, 2017

Gastrotomy closure using bioabsorbable plugs in a canine model.

Theodore J Cios¹, Kevin M Reavis, David R Renton

¹The Ohio State University, Columbus, OH, USA.

Surgical Endoscopy

|August 22, 2007

Summary

A novel bioabsorbable device effectively seals gastric perforations, promoting physiological healing. This study demonstrates its feasibility for durable closure, potentially advancing endoscopic repair techniques.

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Area of Science:

Gastroenterology
Surgical Innovation
Biomaterials Science

Background:

Gastric perforation repair traditionally relies on open or laparoscopic suture closure.
Endolumenal approaches using prosthetic materials offer potential benefits but require further investigation.
The efficacy of bioprosthetics for gastric perforation has not been extensively studied.

Purpose of the Study:

To evaluate the feasibility of repairing gastric perforations using a bioabsorbable device.
To quantify the gross and histological changes at the gastric injury site post-repair.
To assess the sealing capability and healing process facilitated by the bioabsorbable device.

Main Methods:

Twelve canines underwent open gastrotomy with a 1-cm anterior gastric perforation.

More Related Videos

Sleeve Gastrectomy in Mice using Surgical Clips

Sleeve Gastrectomy in Mice using Surgical Clips

Published on: November 14, 2020

Related Experiment Videos

Last Updated: Jul 12, 2026

Techniques of Sleeve Gastrectomy and Modified Roux-en-Y Gastric Bypass in Mice

Techniques of Sleeve Gastrectomy and Modified Roux-en-Y Gastric Bypass in Mice

Published on: March 20, 2017

Sleeve Gastrectomy in Mice using Surgical Clips

Sleeve Gastrectomy in Mice using Surgical Clips

Published on: November 14, 2020

The perforation was sealed using a bioabsorbable device, and intralumenal pH was monitored.

Animals were sacrificed at intervals (1-12 weeks) for gross and histological examination of the injury site.

Main Results:

The bioabsorbable device achieved complete perforation seal without leakage in all canines.
At 1 week, the device maintained integrity with no tissue ingrowth (histological score: -1).
From 4-12 weeks, all sites showed healed injuries, with complete lumenal absorption of the device (histological score: -1 to +1).

Conclusions:

Bioabsorbable devices provide durable closure for gastric perforations, leading to physiological healing.
This method supports the development of advanced endoscopic techniques for hollow viscus perforation closure.
The study highlights the potential of biomaterials in minimally invasive gastrointestinal surgery.