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Updated: Jul 12, 2026
Application of Granger Causality Analysis of the Directed Functional Connection in Alzheimer's Disease and Mild Cognitive Impairment
Published on: August 7, 2017
Nonlinear analysis of brain magnetoencephalographic activity in Alzheimer disease patients
I Abatzoglou1, P Anninos, A Adamopoulos
1Laboratory of Medical Physics, Medical School, Democritus University of Thrace, Alexandroupolis, Greece. abadzoglou@yahoo.gr
Objectives:
Non-linear analysis was applied on MEG signals of Alzheimer Disease (AD) patients in order to investigate the underlying complexity of the brain dynamics.
Materials And Methods:
A Single channel SQUID was used to record the MEG signals in 9 AD patients and 5 normal individuals. The magnetic activity, for each patient, was recorded from a total of 64 points of the skull (32 points from each temporal lobe). Nonlinear analysis was applied in the abnormal MEG points of the brain.
Results:
In AD patients some recorded points were found with high amplitudes and low frequencies in magnetic activity. By applying nonlinear analysis in these records low values in the correlation dimension D of the reconstructed phase space were found.
Conclusions:
SQUID obtained MEG signaling from brains of AD patients showed a lower complexity compared to the brain of normal subjects.
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