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Related Experiment Videos

The relationship between development and evolution through heritable variation.

James M Cheverud1

  • 1Department of Anatomy & Neurobiology, Washington University School of Medicine, 660 S. Euclid Avenue, St. Louis, MO 63110, USA.

Novartis Foundation Symposium
|August 23, 2007
PubMed
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Developmental processes link genotypes to phenotypes, influencing heritable variation and thus evolution. Understanding how development structures variation reveals how evolution itself is structured.

Area of Science:

  • Evolutionary biology
  • Developmental biology
  • Genetics

Background:

  • Darwin's theory of evolution emphasizes natural selection acting on heritable variation.
  • Developmental processes are crucial physiological links between genotypes and phenotypes.
  • Developmental variations can influence the heritable variation available for selection.

Purpose of the Study:

  • To explore the role of development in structuring heritable variation and, consequently, evolution.
  • To investigate how developmental interactions influence patterns of inheritance and co-evolution.
  • To understand the genetic basis of modular inheritance and pleiotropic gene effects.

Main Methods:

  • Review of evolutionary theory and empirical studies on trait inheritance.

Related Experiment Videos

  • Analysis of gene mapping studies to identify patterns of pleiotropic gene effects.
  • Formulation of hypotheses regarding the role of natural selection in shaping modular pleiotropy.

    • Main Results:

    • Features interacting during development tend to be inherited and evolve together.
    • Modular inheritance patterns are linked to modular pleiotropic gene effects.
    • Heritable variation exists in the scope of features influenced by these gene modules.

    Conclusions:

    • Development plays a key role in structuring heritable variation, thereby influencing evolutionary trajectories.
    • Modular pleiotropic gene effects, shaped by natural selection, contribute to the co-evolution of functionally related traits.
    • Considering development's role in variation provides deeper insights into the evolutionary process.