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Updated: Jul 12, 2026
A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products
Published on: October 4, 2019
Agladupols A-E, triterpenoids from Aglaia duperreana
Bo-Jun Xie1, Sheng-Ping Yang, Hua-Dong Chen
1State Key Laboratory fo Drug Research, Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, People's Republic of China.
Abstract:
Three new apotirucallane-type triterpenoids, agladupols A-C (1- 3), and two new tirucallane-type triterpenoids, agladupols D and E (4 and 5), along with four known compounds, were isolated from the leaves and stems of Aglaia duperreana (Meliaceae). The structures of compounds 1- 5 were elucidated by spectroscopic data. A (13)C NMR-based general rule for assignment of the C-21 configuration in the side chain of apotirucallane- and tirucallane-type triterpenoids was proposed. According to this, the relative stereochemistry of 21- O-methyltoosendanpentol (1a), a known compound with the relative configurations of the stereocenters in the side chain undetermined, was completely assigned.
