Central pharmacological effects of long-term application of piracetam in rats

Effect of the 14-day administration of piracetam in a dose of 5 g/kg ip upon the behavior of rats and on the content of biogenic amines and their metabolites in different brain areas was studied. It was shown that the treatment by PI for 14 days produced changes in the rat behavior manifested mainly by inhibition of exploratory activity. Long-term PI administration modified the content of NA, DA and 5-HT and their metabolites in different parts of the brain.