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Updated: Jul 12, 2026

Surfactant Depletion Combined with Injurious Ventilation Results in a Reproducible Model of the Acute Respiratory Distress Syndrome (ARDS)
Published on: April 7, 2021
Acute respiratory distress syndrome induced by oral methadone managed with non-invasive ventilation
1Department of Anaesthesia, Leeds General Infirmary, Great George Street, Leeds LS1 3EX, UK. zoe.tom@ntlworld.com
Abstract:
Non-cardiogenic pulmonary oedema is an uncommon complication of both methadone and heroin overdose, often requiring a period of invasive ventilation due to its severity. We report the successful, early use of non-invasive ventilation in the management of non-cardiogenic pulmonary oedema secondary to a non-fatal overdose of oral methadone.
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