Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Pulmonary Tuberculosis IV

Pulmonary Tuberculosis IV

Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...

Traumatic Brain Injury l: Introduction

Traumatic Brain Injury l: Introduction

DefinitionTraumatic brain injury, or TBI, is a disturbance of normal brain function induced by an external mechanical force, such as a direct blow to the head or a penetrating injury. It can affect both brain structure and function, producing a wide range of clinical outcomes. TBI is a heterogeneous condition, meaning its effects may differ based on the type, location, and severity of the injury.Basis of ClassificationTBI is classified based on severity, injury mechanism, or pathophysiology. In...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Within-host pathogen population diversity predicts treatment response in Tuberculosis.

medRxiv : the preprint server for health sciences·2026

Same author

Bacterial topography of the respiratory tract, including pulmonary site-of-disease, in people with active tuberculosis: a case-control study.

Research square·2026

Same author

Convolutional neural networks quantify antibiotic resistance in Mycobacterium tuberculosis with diagnostic grade accuracy and predict treatment response.

Nature communications·2026

Same author

Bedaquiline resistance in patients with Xpert MTB/RIF Ultra-tested rifampicin-resistant tuberculosis in the Western Cape, South Africa: a prospective study.

The Lancet. Microbe·2026

Same author

Whole-genome sequencing reveals genetic diversity and transmission dynamics of <i>Mycobacterium bovis</i> in South African wildlife.

Microbial genomics·2026

Same author

Undetected rifampicin-resistant tuberculosis associated with rpoB I491F and V170F mutations in Botswana: Diagnostic implications.

Journal of global antimicrobial resistance·2025

Search research articles

Related Experiment Video

Updated: Jul 12, 2026

A Tuberculosis Molecular Bacterial Load Assay (TB-MBLA)

A Tuberculosis Molecular Bacterial Load Assay (TB-MBLA)

Published on: April 30, 2020

A threshold value for the time delay to TB diagnosis.

Pieter W Uys¹, Robin M Warren, Paul D van Helden

¹Division of Molecular Biology and Human Genetics, MRC Center for Molecular and Cellular Biology, Faculty of Health Sciences, Stellenbosch University, Cape Town, Western Cape, Republic of South Africa.

|August 23, 2007

Summary

Reducing delays in diagnosing tuberculosis (TB) is crucial for controlling its spread. Early detection and intervention strategies are essential to prevent TB epidemic escalation in high-incidence communities.

More Related Videos

An Automated Culture System for Use in Preclinical Testing of Host-Directed Therapies for Tuberculosis

An Automated Culture System for Use in Preclinical Testing of Host-Directed Therapies for Tuberculosis

Published on: August 16, 2021

Related Experiment Videos

Last Updated: Jul 12, 2026

A Tuberculosis Molecular Bacterial Load Assay (TB-MBLA)

A Tuberculosis Molecular Bacterial Load Assay (TB-MBLA)

Published on: April 30, 2020

An Automated Culture System for Use in Preclinical Testing of Host-Directed Therapies for Tuberculosis

An Automated Culture System for Use in Preclinical Testing of Host-Directed Therapies for Tuberculosis

Published on: August 16, 2021

Area of Science:

Epidemiology
Infectious Disease Dynamics
Public Health Interventions

Background:

Tuberculosis (TB) transmission is a significant driver of epidemics in high-incidence communities.
Long delays from symptom onset to diagnosis and treatment contribute to high TB transmission rates.
Understanding transmission dynamics is key to effective TB control strategies.

Purpose of the Study:

To analyze the consequences of diagnostic delays in TB epidemics.
To demonstrate the existence of a threshold delay value critical for epidemic control.
To identify strategies for reducing TB incidence through optimized case detection.

Main Methods:

Analysis of diagnostic delays in epidemiologically isolated communities with low HIV incidence.
Mathematical modeling approach avoiding standard differential equation integration for clear, intuitive dynamics.
Quantitative assessment of the relationship between diagnosis time and epidemic escalation.

Main Results:

A critical threshold delay value for TB diagnosis was identified.
Failure to detect sufficient cases before this threshold leads to epidemic escalation.
Typical diagnostic delays significantly impede TB epidemic control.

Conclusions:

Optimizing rapid TB case identification is essential for epidemic control.
Measures to increase the diagnostic threshold value are necessary.
A calculated, aggressive program decreasing diagnosis time is required to reduce TB prevalence.