Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Rapid decrease of GAD 67 content before the convulsion induced by hyperbaric oxygen exposure.

Quan Li1, Meili Guo, Xiongfei Xu

  • 1Department of Diving Medicine, Faculty of Naval Medicine, Second Military Medical University, 800 Xiangyin Road, Shanghai 200433, China.

Neurochemical Research
|August 23, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Correction to "Multienzyme Active Nanozyme for Efficient Sepsis Therapy through Modulating Immune and Inflammation Inhibition".

ACS applied materials & interfaces·2026
Same author

BSA-seq integrated with transcriptomics and metabolomics revealing the candidate genes associated with safflower colors and flavonoid glycosides biosynthesis.

Horticulture research·2026
Same author

Retraction notice to "Hydrogen therapy reduces apoptosis in neonatal hypoxia-ischemia rat model". [Neurosci. Lett. 441 (2008) 167-172].

Neuroscience letters·2026
Same author

Development and Evaluation of the Model for Predicting 10-Year Cardiovascular Mortality in Patients with Ischemic Stroke.

Cerebrovascular diseases (Basel, Switzerland)·2026
Same author

Single-Atom-Engineered Implant Materials with Lactate Dehydrogenase-Like Activity for Sustainable Bone Repair and Regeneration.

Nano letters·2026
Same author

Genome-Wide Identification and Expression Analysis of the NIN-LIKE Protein (NLP) Gene Family in Salvia Miltiorrhiza.

Biochemical genetics·2025
Same journal

Correction to: Dual Antioxidant DH-217 Mitigated Cerebral Ischemia-Reperfusion Injury by Targeting IKKβ/Nrf2/HO-1 Signal Axis.

Neurochemical research·2026
Same journal

Microglia-Dependent BDNF Signaling in the Dentate Gyrus Underlies the Antidepressant Effects of Gardiquimod, a Toll-Like Receptor 7 Agonist, in Chronically Stressed Mice.

Neurochemical research·2026
Same journal

Cryptotanshinone Targets Ferroptosis in Glioma via the EGFR/ROS Signaling Pathway.

Neurochemical research·2026
Same journal

Combined Puerarin and Magnesium Acetyl Taurate Intervention Mitigates Autism-Like Pathology Through Glutamatergic and MAPK Pathway Regulation.

Neurochemical research·2026
Same journal

Long-Term Impact of Early-Life Stress on Hippocampal Apoptotic Gene Expression in BALB/c Mice.

Neurochemical research·2026
Same journal

Minute-Resolution Sampling Reveals Rapid and Stimulus-Specific IL-1β Dynamics During Acute Epileptiform Activity.

Neurochemical research·2026
See all related articles

Hyperbaric oxygen (HBO) exposure can cause seizures. This study found that reduced Glutamic Acid Decarboxylase (GAD) activity, specifically GAD67, during HBO exposure is linked to seizure formation.

Area of Science:

  • Neuroscience
  • Biochemistry
  • Hyperbaric Medicine

Background:

  • Hyperbaric oxygen (HBO) therapy is used for various medical conditions.
  • The exact mechanisms causing seizures during HBO exposure are not fully understood.
  • Glutamic acid decarboxylase (GAD) is crucial for maintaining the central nervous system's (CNS) excitatory-inhibitory balance.

Purpose of the Study:

  • To investigate the impact of HBO on GAD activity and content.
  • To explore the role of GAD in HBO-induced seizures.
  • To differentiate the effects on GAD subtypes GAD65 and GAD67.

Main Methods:

  • In vivo animal models were used to study HBO effects.
  • Primary neuronal cultures were utilized for in vitro experiments.

Related Experiment Videos

  • GAD activity and GAD65/GAD67 content were measured under HBO exposure.

    • Main Results:

    • HBO exposure altered GAD activity in a rise-and-fall pattern during the latent seizure period.
    • At seizure onset, GAD activity returned to normal levels.
    • GAD67 content decreased significantly during the latent period, while GAD65 remained stable.

    Conclusions:

    • GAD is highly sensitive to HBO exposure.
    • The reduction in GAD67 content is strongly associated with HBO-induced seizures.
    • GAD67 may be a key factor in the pathophysiology of HBO-induced convulsions.