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MTHFR C677T polymorphism and osteoporotic fractures
C Valero1, M A Alonso, M T Zarrabeitia
11Department of Internal Medicine, Hospital U. M. Valdecilla, University of Cantabria, Santander, Spain.
Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Metabolisme
|August 23, 2007
Summary
The C677T polymorphism in the methylenetetrahydrofolate reductase (MTHFR) gene is not linked to osteoporotic fractures. Further research is needed to explore potential associations in specific populations.
Area of Science:
- Genetics and Molecular Biology
- Bone Health and Osteoporosis Research
Background:
- The methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism (rs1801133) has been inconsistently linked to cardiovascular events and osteoporosis risk.
- Previous studies on the association between MTHFR C677T polymorphism and osteoporotic fractures have yielded controversial results.
Purpose of the Study:
- To investigate the relationship between the MTHFR C677T polymorphism and the risk of osteoporotic fractures using a case-control study design.
Main Methods:
- A case-control study was conducted involving 823 subjects, including 365 controls, 136 with vertebral fractures, and 322 with hip fractures.
- The MTHFR C677T polymorphism was genotyped using a Taqman assay.
- A meta-analysis was performed, combining the current study's data with previous published reports.
Main Results:
- The distribution of MTHFR genotypes did not differ significantly between fracture patients and control groups.
- Age-adjusted odds ratios (OR) for hip and vertebral fractures showed no significant association with the MTHFR TT genotype compared to TC/CC genotypes in both men and women.
- The meta-analysis confirmed a lack of association between MTHFR C677T polymorphism and vertebral (OR=1.1, p=0.65) or peripheral fractures (OR=1.2, p=0.45), although significant heterogeneity was noted.
Conclusions:
- The MTHFR C677T polymorphism does not appear to be associated with the overall risk of osteoporotic fractures.
- Significant heterogeneity in previous study results suggests the need for further investigations in specific population subgroups to clarify potential influences.
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