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Related Concept Videos

Differentiation of Common Myeloid Progenitor Cells01:15

Differentiation of Common Myeloid Progenitor Cells

Common myeloid progenitors (CMPs) are oligopotent cells that can differentiate into granulocytes and macrophages. Granulocytes and macrophages are essential for protecting the body against bacterial, viral, or fungal infections. They migrate from the bone marrow into the circulating blood to reach specific tissue sites where they differentiate and help in immune surveillance. However, they survive only for a few days and must be continuously made available to the organism to maintain a robust...
Regulation of Hematopoietic Stem Cells01:01

Regulation of Hematopoietic Stem Cells

All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the daughter...
Mesenchymal Stem Cells01:19

Mesenchymal Stem Cells

Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their access...
Multipotency of Hematopoietic Stem Cells01:19

Multipotency of Hematopoietic Stem Cells

The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...

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Related Experiment Video

Updated: Jul 12, 2026

Preparation of Myeloid Derived Suppressor Cells (MDSC) from Naive and Pancreatic Tumor-bearing Mice using Flow Cytometry and Automated Magnetic Activated Cell Sorting (AutoMACS)
14:15

Preparation of Myeloid Derived Suppressor Cells (MDSC) from Naive and Pancreatic Tumor-bearing Mice using Flow Cytometry and Automated Magnetic Activated Cell Sorting (AutoMACS)

Published on: June 18, 2012

Myeloid-derived suppressor cells.

Srinivas Nagaraj1, Dmitry I Gabrilovich

  • 1H. Lee Moffitt Cancer Center, University of South Florida, Tampa, FL, USA.

Advances in Experimental Medicine and Biology
|August 24, 2007
PubMed
Summary

Tumor cells evade immune detection through T cell tolerance. Myeloid-derived suppressor cells (MDSCs) promote this tolerance, hindering anti-tumor responses by suppressing T cells through various mechanisms.

Area of Science:

  • Immunology
  • Oncology
  • Cellular Biology

Background:

  • Tumor-specific T cell tolerance is a primary mechanism of tumor immune evasion.
  • Myeloid-derived suppressor cells (MDSCs) are key players in establishing a pro-tumor immune microenvironment.
  • MDSCs are found in both preclinical tumor models and human cancer patients.

Purpose of the Study:

  • To elucidate the mechanisms by which MDSCs induce antigen-specific T cell tolerance.
  • To provide a comprehensive overview of MDSC-mediated immunosuppression in cancer.

Main Methods:

  • Review of existing literature on MDSCs and T cell tolerance.
  • Analysis of experimental data from animal tumor models and human studies.
  • Focus on the molecular and cellular pathways employed by MDSCs.

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Isolation and Characterization of Neutrophils with Anti-Tumor Properties

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Related Experiment Videos

Last Updated: Jul 12, 2026

Preparation of Myeloid Derived Suppressor Cells (MDSC) from Naive and Pancreatic Tumor-bearing Mice using Flow Cytometry and Automated Magnetic Activated Cell Sorting (AutoMACS)
14:15

Preparation of Myeloid Derived Suppressor Cells (MDSC) from Naive and Pancreatic Tumor-bearing Mice using Flow Cytometry and Automated Magnetic Activated Cell Sorting (AutoMACS)

Published on: June 18, 2012

Functional Characterization of Regulatory Macrophages That Inhibit Graft-reactive Immunity
08:41

Functional Characterization of Regulatory Macrophages That Inhibit Graft-reactive Immunity

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Isolation and Characterization of Neutrophils with Anti-Tumor Properties
10:15

Isolation and Characterization of Neutrophils with Anti-Tumor Properties

Published on: June 19, 2015

Main Results:

  • MDSCs accumulate in the tumor microenvironment, contributing to immune suppression.
  • MDSCs utilize diverse strategies to inhibit T cell function and promote tolerance.
  • These mechanisms include direct cell-cell contact, secretion of immunosuppressive factors, and metabolic disruption.

Conclusions:

  • MDSCs are critical mediators of tumor-induced T cell tolerance.
  • Understanding MDSC mechanisms is essential for developing effective cancer immunotherapies.
  • Targeting MDSCs may represent a promising therapeutic strategy to overcome tumor immune escape.