Related Experiment Video
Updated: Jul 12, 2026

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model
Published on: March 17, 2023
"Thyrotoxic psychosis" associated with subacute thyroiditis
1Division of Endocrinology, Diabetes, and Metabolism, University of South Carolina School of Medicine, Columbia, SC, USA. arizvi@gw.mp.sc.edu
Abstract:
Severe psychiatric derangements are a rare manifestation of Graves disease or toxic goiter. An 18-year-old male college student was hospitalized with depression and psychotic behavior. He was found to have thyrotoxicosis due to subacute thyroiditis, as evidenced by a reduced radioactive iodine uptake, elevated thyroglobulin level, and spontaneous remission into a hypothyroid phase. His behavioral abnormalities resolved with progressive normalization of thyroid function. To our knowledge, this is the first reported case of the self-limited condition of subacute thyroiditis causing 'thyrotoxic psychosis' and serves to remind clinicians of this association when treating patients in clinical practice.
Related Concept Videos
Hyperthyroidism I: Introduction
Graves Disease II: Pathophysiology
Hyperthyroidism II: Pathophysiology
Graves' Disease I: Introduction
Hypothyroidism II: Pathophysiology
Goiter