Low-fluoride dentifrices with reduced pH: fluoride concentration in whole saliva and bioavailability

This double-blind study assessed the fluoride (F) concentration in whole saliva and F bioavailability after the use of low-F dentifrices with reduced pH. Whole saliva was collected from 10 volunteers after brushing with: experimental dentifrices (pH 5.5) 275, 550 and 1,100 ppm F; commercial 500 ppm F, pH 6.9 and a 'gold standard' 1,100 ppm F, pH 6.5. To analyze F bioavailability, 9 volunteers ingested weights of four dentifrices equivalent to 2 mg F: 1,500 ppm F/MFP/CaCO3, pH 9.5; 1,100 ppm F/NaF/silica, pH 5.5; 1,100 ppm F/NaF/silica, pH 7.0 and 1,100 ppm F/NaF/silica, pH 6.5 ('gold standard'). Ductal saliva and urine were collected. F was analyzed by electrode. Data were tested using ANOVA and Tukey's post hoc test (p < 0.05). The 550 ppm F/pH 5.5 dentifrice was similar to the 'gold standard' in its effect on whole saliva F concentration. The area under the curve of ductal saliva F concentration x time and urinary F excretion rates did not differ among the dentifrices. The results show that acidic low-F dentifrices are effective in increasing salivary F concentration and pH reduction does not seem to affect their F bioavailability.