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Updated: Jul 12, 2026
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Evaluation of a Reliable Biomarker in a Cecal Ligation and Puncture-Induced Mouse Model of Sepsis
Published on: December 9, 2022
Exogenous arginine in sepsis.
Yvette C Luiking1, Nicolaas E P Deutz
1Center for Translational Research on Aging & Longevity, Donald W. Reynolds Institute on Aging, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Critical Care Medicine
|September 22, 2007
Summary
Arginine supplementation in sepsis is controversial due to varied study results. Recent findings suggest arginine can be safely administered to septic patients, warranting further research into its benefits.
Area of Science:
- Critical care medicine
- Nutritional biochemistry
- Sepsis pathophysiology
Background:
- Sepsis is a life-threatening condition characterized by arginine deficiency.
- Reduced arginine levels in sepsis are linked to endothelial dysfunction, catabolism, and poor outcomes.
- Arginine metabolism alterations contribute to sepsis severity.
Purpose of the Study:
- To review the controversial findings of exogenous arginine supplementation in sepsis.
- To explore potential beneficial and detrimental mechanisms of arginine in sepsis.
- To present new data on arginine administration safety in septic patients.
Main Methods:
- Review of existing human and animal studies on arginine supplementation in sepsis.
- Analysis of factors influencing arginine supplementation outcomes (dose, timing, route).
- Presentation of a recent study assessing arginine administration in septic patients.
Main Results:
- Arginine supplementation in sepsis yields controversial and variable results across studies.
- Potential benefits include improved metabolism, microcirculation, immune function, and antioxidant effects.
- A recent study found arginine administration safe in septic patients without significant hemodynamic impact.
Conclusions:
- The role of arginine supplementation in sepsis requires further investigation due to inconsistent data.
- Factors like sepsis severity and supplementation protocols influence outcomes.
- Arginine administration appears safe in critically ill septic patients, supporting further research.
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