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Understanding FOXP3: progress towards achieving transplantation tolerance

Elaine Long1, Kathryn J Wood

  • 1Transplant Research Immunology Group, Nuffield Department of Surgery, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom. elaine.long@nds.ox.ac.uk

Transplantation
|August 24, 2007
PubMed

Regulatory T cells (Treg) suppress immune responses, making them an exciting therapeutic target for achieving operational transplant tolerance. Recent observations have identified forkhead box P3 (FOXP3) as a master gene required for the development and function of Treg. Improving our understanding of FOXP3 may facilitate methods for identifying and generating Treg.

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