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Related Concept Videos

Drug Dosing: Geriatric Patients01:15

Drug Dosing: Geriatric Patients

Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
Pharmacodynamics in Geriatric Patients: Effects of Age01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution01:00

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution

Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are not...
Muscle Recovery and Fatigue01:24

Muscle Recovery and Fatigue

Muscle fatigue refers to the decline in a muscle's ability to maintain the force of contraction after prolonged activity. It primarily stems from changes within muscle fibers. Even before experiencing muscle fatigue, one may feel tired and have the urge to stop the activity. This response, known as central fatigue, occurs due to changes in the central nervous system, namely the brain and spinal cord. While there is no single mechanism that induces fatigue, it may serve as a protective response...
Fatigue01:21

Fatigue

Fatigue occurs when materials rupture under repeated or fluctuating loads, even at stress levels far below their static breaking strength. It typically results in brittle failure, even for ductile materials. It is a critical consideration in designing machines and structural components subjected to repetitive or varying loads. The nature of these loadings can range from fluctuating loads like unbalanced pump impellers causing vibrations to repeatedly bending a thin steel rod wire back and forth...
Heart Failure VII: Nursing Interventions01:30

Heart Failure VII: Nursing Interventions

The first step in nursing management of a patient with heart failure involves thoroughly assessing the patient's medical history.Subjective Data: Obtain the patient's medical history of coronary artery disease, hypertension, myocardial infarction, and symptoms like dyspnea, orthopnea, and paroxysmal nocturnal dyspnea.Objective Data: Conduct a physical examination to identify findings such as jugular vein distention, pulmonary crackles, tachycardia, murmurs, peripheral edema, and vital signs,...

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Related Experiment Video

Updated: Jul 12, 2026

Acupoint Application as a Traditional Chinese Medicine Treatment for Fatigue Associated with Chronic Obstructive Pulmonary Disease
04:24

Acupoint Application as a Traditional Chinese Medicine Treatment for Fatigue Associated with Chronic Obstructive Pulmonary Disease

Published on: September 5, 2025

Fatigue: implications for the elderly.

Jeannette Y Wick1, Joanne LaFleur

  • 1National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.

The Consultant Pharmacist : the Journal of the American Society of Consultant Pharmacists
|August 24, 2007
PubMed
Summary

Fatigue is a common symptom, often linked to other illnesses or medications, with causes identified in only 10% of cases. Routine assessment and management, including lifestyle changes, are key for addressing this widespread issue.

Area of Science:

  • Gerontology
  • Internal Medicine
  • Neurology

Background:

  • Fatigue is a prevalent symptom with unknown prevalence due to under-reporting, affecting up to 50% of older adults.
  • While causes vary, fatigue is often a secondary consequence of underlying illnesses and medications.

Purpose of the Study:

  • To review the common causes and management strategies for sporadic and chronic fatigue.
  • To highlight the importance of routine assessment and the role of lifestyle interventions.

Main Methods:

  • Literature review of studies on fatigue etiology and management.
  • Analysis of the link between fatigue and various medical conditions and treatments.

Main Results:

  • An underlying cause for fatigue is identified in only up to 10% of cases.

Related Experiment Videos

Last Updated: Jul 12, 2026

Acupoint Application as a Traditional Chinese Medicine Treatment for Fatigue Associated with Chronic Obstructive Pulmonary Disease
04:24

Acupoint Application as a Traditional Chinese Medicine Treatment for Fatigue Associated with Chronic Obstructive Pulmonary Disease

Published on: September 5, 2025

  • Fatigue is prominently associated with sleep disorders, depression, heart disease, Parkinson's disease, anemia, and cancer.

    • Conclusions:

    • Routine assessment of fatigue and its consequences is recommended.
    • Empiric treatment focusing on symptom management, with a preference for agents having fewer side effects, is the current norm.
    • Exercise, diet, and sleep hygiene are beneficial for managing fatigue symptoms.