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Updated: Jul 12, 2026

In Silico Clinical Trials for Cardiovascular Disease
Published on: May 27, 2022
Discontinued drugs in 2006: cardiovascular drugs translational medicine perspective
Giora Z Feuerstein1, Robert R Ruffolo
1Discovery Translational Medicine, Wyeth Research, Collegeville, PA 19426, USA. feuersg@wyeth.com
Abstract:
This perspective on discontinued cardiovascular drugs is the first in a series of papers on drugs dropped from clinical development in 2006. The compounds described in this perspective have been removed from development in various stages and for different reasons. This paper hereby provides a translational medicine perspective on these compounds based on information available through the Pharmaprojects pipeline database. In particular, potential gaps in the pipeline, due to a lack of biomarkers and translational medicine perspectives are emphasized.
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