Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Does spike timing-dependent synaptic plasticity underlie memory formation?

Johannes J Letzkus1, Björn M Kampa, Greg J Stuart

  • 1Division of Neuroscience, The John Curtin School of Medical Research, Australian National University, Canberra, Australian Capital Territory, Australia.

Clinical and Experimental Pharmacology & Physiology
|August 24, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Environmental Context Modulates Habituation of Visually Evoked Defensive Behavior.

eNeuro·2026
Same author

A population approach to cortical GABAergic interneuron function.

Neuron·2026
Same author

Non-reciprocal callosal projections and input gradients underlie interhemispheric communication in binocular visual cortex.

Cell reports·2026
Same author

Lack of cross modal plasticity potentially linked to ongoing activation of visual cortex and superior colliculus in the rd10 mouse model of retinitis pigmentosa.

Cerebral cortex (New York, N.Y. : 1991)·2025
Same author

Biologically grounded neocortex computational primitives implemented on neuromorphic hardware improve vision transformer performance.

Proceedings of the National Academy of Sciences of the United States of America·2025
Same author

Microglia-neuron crosstalk through Hex-GM2-MGL2 maintains brain homeostasis.

Nature·2025
Same journal

Relationship Between Long-Term Exposure to Airborne Particulate Matter and the Intrinsic Capacity of Middle-Aged and Older Adults in China: A Retrospective Cohort Study Based on CHARLS.

Clinical and experimental pharmacology & physiology·2026
Same journal

Dapagliflozin Improves Mitochondrial Function to Reduce the Risk of Atrial Fibrillation in a High-Glucose Environment by Activating the AMPK/PGC-1α/SIRT3 Signalling Pathway.

Clinical and experimental pharmacology & physiology·2026
Same journal

Hypertension-Mediated Organ Damage: Pathophysiological Mechanisms, Clinical Consequences, and Implications for Early Risk Stratification.

Clinical and experimental pharmacology & physiology·2026
Same journal

Saikosaponin D Alleviates Atherosclerosis by Regulating Autophagy and Senescence of VSMCs via Inhibiting EPHB2.

Clinical and experimental pharmacology & physiology·2026
Same journal

Noninvasively Evaluating the Cerebral Blood Flow Changes After Surgery in Adult Moyamoya Patients Using 3D Pulsed Arterial Spin Labelling MRI.

Clinical and experimental pharmacology & physiology·2026
Same journal

Targeting S100A8/A9 Ameliorates Heart Failure with Preserved Ejection Fraction by Modulating TLR4/NF-κB-Mediated Inflammation.

Clinical and experimental pharmacology & physiology·2026
See all related articles

Spike-timing-dependent plasticity (STDP) is a key mechanism for learning and memory. This review highlights evidence for STDP

Area of Science:

  • Neuroscience
  • Cellular Biology
  • Cognitive Science

Background:

  • Synaptic plasticity is crucial for learning and memory.
  • The precise induction mechanisms of synaptic plasticity remain debated.
  • Spike-timing-dependent plasticity (STDP) is a candidate mechanism for associative learning.

Purpose of the Study:

  • To review evidence for STDP as a mechanism underlying learning.
  • To discuss cellular mechanisms and in vivo induction of STDP.
  • To evaluate STDP's role in normal behavior and sensory map plasticity.

Main Methods:

  • Review of in vitro and in vivo experimental studies on STDP.
  • Analysis of cellular mechanisms of STDP.
  • Examination of STDP induction during behavior.

Related Experiment Videos

Main Results:

  • STDP is a robust phenomenon observed in vivo across various species and brain regions.
  • STDP is likely involved in sensory map plasticity in the neocortex.
  • Evidence supports STDP's role in certain forms of learning.

Conclusions:

  • STDP is a well-established in vivo mechanism.
  • STDP is a probable driver of neocortical sensory map plasticity.
  • Further research is needed to confirm STDP's role in complex learning.