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Related Concept Videos

Skin Diseases and Disorders01:23

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Pulmonary Tuberculosis III01:31

Pulmonary Tuberculosis III

Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
The first classification is based on the development of the disease, and it includes the following categories:
Pulmonary Tuberculosis IV01:26

Pulmonary Tuberculosis IV

Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
Tuberculosis01:23

Tuberculosis

Tuberculosis (TB) remains a significant global health concern, primarily targeting the lungs and spreading through airborne transmission. Infection begins when aerosolized droplet nuclei, expelled by an individual with active TB, are inhaled by another person. These microscopic particles carry Mycobacterium tuberculosis, the causative agent of TB. Upon reaching the alveoli, the bacilli are engulfed by alveolar macrophages. However, due to their specialized lipid-rich cell wall, these pathogens...
Fungal Phylum Microsporidia01:28

Fungal Phylum Microsporidia

Microsporidia are a group of obligate intracellular fungi that were initially classified as protists but were later reclassified based on phylogenetic, molecular, and structural evidence linking them to the Chytridiomycota. These unicellular, non-motile organisms are highly specialized parasites that infect a wide range of animal hosts, including humans. They have evolved extensive genomic and metabolic reductions, making them highly dependent on their hosts for survival.Morphology and Genomic...
Pulmonary Tuberculosis II01:28

Pulmonary Tuberculosis II

Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...

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Related Experiment Videos

Sporotrichoid cutaneous tuberculosis.

V Ramesh1

  • 1Department of Dermatology and STD, Safdarjang Hospital and V.M.Medical College, New Delhi, India. weramesh@hotmail.com

Clinical and Experimental Dermatology
|August 24, 2007
PubMed
Summary

This study describes three cases of sporotrichoid cutaneous tuberculosis in children and young adults. Diagnosis relied on clinical signs, tuberculin tests, and histopathology, with successful treatment using anti-tubercular therapy.

Area of Science:

  • Dermatology
  • Infectious Diseases
  • Mycobacteriology

Background:

  • Cutaneous tuberculosis presents with diverse clinical manifestations.
  • Sporotrichoid spread is typically associated with less pathogenic mycobacteria.
  • Understanding rare presentations aids in accurate diagnosis and treatment.

Observation:

  • Three cases of sporotrichoid cutaneous tuberculosis are presented: two with lupus vulgaris on lower limbs and one with scrofuloderma on an arm.
  • Mycobacterial cultures were negative in all cases.
  • Diagnosis was established through clinical presentation, positive tuberculin skin tests, and characteristic histopathological findings.

Findings:

  • The sporotrichoid pattern in scrofuloderma mimicked sporotrichosis more closely than in lupus vulgaris.

Related Experiment Videos

  • Histopathology revealed granulomatous dermatitis consistent with tuberculosis.
  • All patients responded well to Directly Observed Treatment, Short-course (DOTS) anti-tubercular therapy.
  • Implications:

    • Sporotrichoid cutaneous tuberculosis can occur even with negative mycobacterial cultures.
    • The presentation is more common in children and adolescents, possibly due to lymphatic drainage and physical activity.
    • This highlights the importance of considering tuberculosis in differential diagnoses for sporotrichoid skin lesions, especially in younger populations.