Related Experiment Video

Updated: Jul 12, 2026

Direct Restart of a Replication Fork Stalled by a Head-On RNA Polymerase

Direct Restart of a Replication Fork Stalled by a Head-On RNA Polymerase

Published on: April 29, 2010

Replication licensing: oops! ... I did it again

Jerome Korzelius¹, Sander van den Heuvel

¹Division of Developmental Biology, Faculty of Science, Utrecht University, Padualaan 8, 3584 CH Utrecht, The Netherlands.

Current Biology : CB

|August 24, 2007

Abstract:

All eukaryotes use multiple controls to restrict DNA replication to once per cell cycle. Nevertheless, inactivation of a single gene, cul-4, causes massive re-replication in Caenorhabditis elegans. A novel study explains this dramatic phenotype by demonstrating that the CUL-4 E3 ligase simultaneously controls two critical licensing factors: CDT-1 and CDC-6.

More Related Videos

Antibiotic Dereplication Using the Antibiotic Resistance Platform

Antibiotic Dereplication Using the Antibiotic Resistance Platform

Published on: October 17, 2019

Related Concept Videos

Replication in Eukaryotes

Replication in Eukaryotes

Replication in Eukaryotes

Replication in Eukaryotes

In eukaryotic cells, DNA replication is highly conserved and tightly regulated. Multiple linear chromosomes must be duplicated with high fidelity before cell division, so there are many proteins that fulfill specialized roles in the replication process. Replication occurs in three phases: initiation, elongation, and termination, and ends with two complete sets of chromosomes in the nucleus.
Many Proteins Orchestrate Replication at the Origin
Eukaryotic replication follows many of the same...

Replication in Eukaryotes

Replication in Eukaryotes

Replication in Eukaryotes

Replication in Eukaryotes

In eukaryotic cells, DNA replication is highly conserved and tightly regulated. Multiple linear chromosomes must be duplicated with high fidelity before cell division, so there are many proteins that fulfill specialized roles in the replication process. Replication occurs in three phases: initiation, elongation, and termination, and ends with two complete sets of chromosomes in the nucleus.
Many Proteins Orchestrate Replication at the Origin
Eukaryotic replication follows many of the same...

Replication in Prokaryotes

Replication in Prokaryotes

Replication in Prokaryotes

Replication in Prokaryotes

Articles linked to this work by shared authors, journal, and citation graph.

Engineered chromatin readers track damaged chromatin dynamics in live cells and animals.

Nature communications·2025

The First of Us: Ophiocordyceps use a novel scramblase-binding peptide to manipulate zombie ants.

bioRxiv : the preprint server for biology·2025

A bHLH interaction code controls bipotential differentiation and self-renewal in the Drosophila gut.

Cell reports·2025

Stem cell mTOR signaling directs region-specific cell fate decisions during intestinal nutrient adaptation.

Science advances·2024

Alternatives to the in-person anaesthetist-led preoperative assessment in adults undergoing low-risk or intermediate-risk surgery: A scoping review.

European journal of anaesthesiology·2023

Caenorhabditis elegans MES-3 is a highly divergent ortholog of the canonical PRC2 component SUZ12.

iScience·2022

See all related articles