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Trace element pattern in patients with fibromyalgia.

Ingegerd Rosborg1, E Hyllén, J Lidbeck

  • 1Inst of Chemical Engineering, Lund University, SE-223 62 Lund, Sweden. rosborg@spray.se

The Science of the Total Environment
|August 24, 2007
PubMed
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This study investigated trace element levels in fibromyalgia patients, finding no significant abnormalities in blood or urine. The results do not support the hypothesis that trace element imbalances contribute to fibromyalgia development.

Area of Science:

  • Biochemistry
  • Clinical Chemistry
  • Trace Element Research

Background:

  • Fibromyalgia (FM) is a chronic pain condition.
  • Trace element imbalances have been hypothesized to contribute to FM pathogenesis.
  • Previous research has suggested a link between altered trace element status and FM.

Purpose of the Study:

  • To investigate trace element status in female fibromyalgia patients compared to healthy controls.
  • To determine concentrations of approximately 30 trace elements and ions in blood, urine, and drinking water.
  • To assess the potential role of trace element abnormalities in the development of fibromyalgia.

Main Methods:

  • Study included 38 female fibromyalgia patients and 41 age/geographically matched controls.
  • Inductively coupled plasma mass spectrometry (ICP-MS) and ICP-optical emission spectroscopy (ICP-OES) were used.

Related Experiment Videos

  • Analysis of trace elements in whole blood, urine, and drinking water.

    • Main Results:

    • Elevated blood concentrations of Cadmium (Cd), Cobalt (Co), Copper (Cu), Iron (Fe), Selenium (Se), Tin (Sn), and Zinc (Zn) were observed in FM patients (p<0.046).
    • Increased urinary excretion of Silver (Ag) was noted in FM patients (p=0.003).
    • Most element concentrations in blood and urine fell within established reference intervals, suggesting limited clinical significance.

    Conclusions:

    • The study did not find abnormal trace element levels in fibromyalgia patients' blood or urine.
    • The findings do not support the hypothesis that trace element abnormalities are a significant factor in fibromyalgia development.
    • Further research may be needed to explore other potential contributing factors to fibromyalgia.