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Published on: July 20, 2022

Predictors of ventricular dysfunction and coronary artery disease in Iranian patients with left bundle branch block

S Ghaffari, N Rajabi, A Alizadeh

    International Journal of Cardiology
    |August 24, 2007
    PubMed

    Insights

    Patients with coronary artery disease (CAD) and left bundle branch block (LBBB) face higher mortality. Identifying CAD presence and severity in LBBB patients offers prognostic insights, aiding clinical decision-making and patient outcomes.

    Area of Science:

    • Cardiology
    • Clinical Medicine
    • Diagnostic Imaging

    Background:

    • Patients with coronary artery disease (CAD) and left bundle branch block (LBBB) exhibit elevated cardiovascular mortality.
    • Accurate assessment of CAD severity in LBBB patients is crucial for prognostic stratification.

    Purpose of the Study:

    • To evaluate the prevalence of CAD and left ventricular (LV) dysfunction in patients with LBBB and suspected CAD.
    • To identify predictors of CAD and LV dysfunction in this patient cohort.

    Main Methods:

    • A cross-sectional study involving 219 patients with LBBB and suspected CAD.
    • Coronary angiography was performed to assess for CAD.
    • Left ventricular ejection fraction (LVEF) was evaluated to determine LV dysfunction.

    Main Results:

    • Coronary artery disease (CAD) was detected in 56.3% of patients.
    • Left ventricular (LV) dysfunction (LVEF <50%) was observed in 67.1% of patients.
    • Predictors of CAD included advanced age, male gender, chest pain, and LVEF <50%. Predictors of LV dysfunction included older age, male gender, diabetes mellitus, and angiographically documented CAD.

    Conclusions:

    • The study highlights a high prevalence of CAD and LV dysfunction in LBBB patients.
    • Specific clinical factors predict CAD and LV dysfunction, informing risk assessment.
    • Prognostic information derived from CAD assessment in LBBB patients is clinically valuable.

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