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VDR gene variants associate with cognitive function and depressive symptoms in old age
Maris Kuningas1, Simon P Mooijaart, Jelle Jolles
1Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands. M.Kuningas@lumc.nl
Neurobiology of Aging
|August 24, 2007
Summary
Genetic variations in the vitamin D receptor (VDR) gene are linked to cognitive decline and depression in older adults. Specific VDR gene variants may increase susceptibility to age-related cognitive and mood changes.
Area of Science:
- Neuroscience
- Genetics
- Gerontology
Background:
- Emerging research suggests a role for vitamin D in brain function.
- The vitamin D receptor (VDR) gene is a key mediator of vitamin D's effects.
- Understanding genetic influences on cognitive aging and mood disorders is crucial.
Purpose of the Study:
- To investigate the association between genetic variations in the VDR gene and cognitive functioning in old age.
- To examine the relationship between VDR gene polymorphisms and depressive symptoms in the elderly.
- To explore potential links between VDR gene variants, cognitive function, and mood.
Main Methods:
- Prospective population-based study (Leiden 85-plus Study) with 563 participants.
- Genotyping of VDR gene polymorphisms (Cdx-2, FokI, BsmI, ApaI, TaqI) and haplotypes.
- Cognitive functioning tests and assessment of depressive symptoms.
Main Results:
- Worse cognitive performance was associated with BsmI and TaqI polymorphisms, and haplotype 2 (BAt).
- Carriers of the ApaI variant-allele and haplotype 1 (baT) showed better cognitive functioning and fewer depressive symptoms.
- No association was found between VDR gene variants, calcium levels, or mortality, ruling out these as confounding factors.
Conclusions:
- Genetic variance in the VDR gene significantly influences susceptibility to age-related cognitive decline.
- Specific VDR gene variations are associated with both cognitive functioning and depressive symptoms in older individuals.
- These findings highlight the role of VDR genetic polymorphisms in the aging brain and mental health.
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