Related Experiment Video

Updated: Jul 12, 2026

Disruption of the Mouse Blood-Brain Barrier by Small Extracellular Vesicles from Hypoxic Human Placentas
05:31

Disruption of the Mouse Blood-Brain Barrier by Small Extracellular Vesicles from Hypoxic Human Placentas

Published on: January 26, 2024

[Role of platelet-derived growth factor in the pathogenesis of preeclampsia]

Hui Meng1, Fu-Fan Zhu, Chen-Hong Wang

  • 1Department of Obstetrics and Gynecology, Guangzhou Women and Children's Hospital, Guangzhou 510180, China. mhwd2@hotmail.com

Nan Fang Yi Ke Da Xue Xue Bao = Journal of Southern Medical University
|August 24, 2007
PubMed

Insights

Platelet-derived growth factor (PDGF) is linked to preeclampsia (PRE) development. Elevated PDGF-BB serum levels and PDGF-B mRNA in decidual blood vessels were observed in PRE patients, suggesting a key role in the condition.

Area of Science:

  • Reproductive biology
  • Vascular biology
  • Pathophysiology

Background:

  • Preeclampsia (PRE) is a serious pregnancy complication.
  • The role of platelet-derived growth factor (PDGF) in PRE pathogenesis is not fully understood.

Purpose of the Study:

  • To investigate the association between PDGF and the development of preeclampsia.
  • To examine PDGF-BB serum levels and PDGF-B mRNA expression in the decidua of women with and without PRE.

Main Methods:

  • Enzyme-linked immunosorbent assay (ELISA) was used to quantify serum PDGF-BB levels.
  • In situ hybridization determined PDGF-B mRNA expression in decidual blood vessels.
  • Study included 13 normal pregnant women and 20 with preeclampsia.

Main Results:

  • Serum PDGF-BB levels were significantly higher in the preeclampsia group compared to the normal group (83.54 ± 34.52 vs 39.61 ± 18.20, P<0.001).
  • PDGF-B mRNA expression in decidual blood vessels was also significantly elevated in the preeclampsia group (P<0.001).
  • A positive correlation was found between serum PDGF levels and decidual PDGF-B mRNA expression (r=0.603, P<0.001).

Conclusions:

  • PDGF is implicated in the pathological changes of decidual blood vessels.
  • Elevated serum PDGF and increased PDGF-B mRNA expression in decidual blood vessels may contribute significantly to preeclampsia pathogenesis.
Abstract

More Related Videos

Trophoblast Cell Recovery from Angiogenesis-Tube Formation Assay for Differentiation Marker Expression Analysis05:30

Trophoblast Cell Recovery from Angiogenesis-Tube Formation Assay for Differentiation Marker Expression Analysis

Published on: November 8, 2024

Related Concept Videos

Formation of the Platelet Plug01:22

Formation of the Platelet Plug

The platelet phase, the second stage of hemostasis, commences around 15-20 seconds after an injury. It follows and overlaps with the vascular phase, during which blood vessels constrict to minimize blood loss.
As the injured blood vessel contracts, endothelial cells undergo contraction, revealing collagen fibers in the basement membrane and underlying connective tissue. Furthermore, the plasma membrane of endothelial cells becomes adhesive, preparing the site for platelet adhesion. Platelets...
Structure and Function of Platelets01:18

Structure and Function of Platelets

The cell fragments known as platelets are disc-shaped, with an average diameter of about 3 μm and a thickness of roughly 1 μm. They play a crucial role in the body's vascular clotting system, which also involves plasma proteins, blood cells, and blood vessel tissues.
Platelets are continually replenished, circulating in the bloodstream for 9-12 days before being removed by phagocytes, primarily in the spleen. A microliter of circulating blood contains between 150,000 and 450,000 platelets, with...
Antiplatelet Drugs: Prostaglandin Synthesis, P2Y12 and Glycoprotein IIb/IIIa Inhibitors01:20

Antiplatelet Drugs: Prostaglandin Synthesis, P2Y12 and Glycoprotein IIb/IIIa Inhibitors

Antiplatelet drugs emerge as frontline defenders against the insidious threat of thromboembolic diseases, where abnormal clots obstruct vital blood vessels. These drugs stand as bulwarks, inhibiting platelet aggregation and clot formation, thereby mitigating the risk of life-threatening conditions like myocardial infarction, coronary artery disease, and thrombotic strokes.
Prostaglandin synthesis inhibitors, exemplified by the widely known aspirin, wield their power by irreversibly acetylating...
Regulation of Angiogenesis and Blood Supply01:24

Regulation of Angiogenesis and Blood Supply

Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits.  Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl hydroxylase and factor...
Clot Retraction and Fibrinolysis01:16

Clot Retraction and Fibrinolysis

After a fibrin clot is formed, the next step is clot retraction, a vital process facilitated by platelet contractile proteins, such as actin and myosin. These proteins pull the fibrin strands closer together and condense the clot. This action reduces the size of the clot, creating a smaller, denser structure that effectively seals off the damaged vessel. Clot retraction consolidates the clot and helps with wound healing by bringing the edges of the damaged blood vessel closer together.
Hormonal Regulation01:33

Hormonal Regulation

The renin-aldosterone system is an endocrine system which guides the renal absorption of water and electrolytes, thus managing blood pressure and osmoregulation. Activation of the system begins in the kidneys with a small cluster of cells adjacent to the afferent and efferent blood vessels of the renal corpuscle. As the nephrons are filtering blood, juxtaglomerular cells monitor blood pressure. If they detect a decrease in pressure, they release the hormone renin into the bloodstream.