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Updated: Jul 12, 2026

09:57
Passive Administration of Monoclonal Antibodies Against H. capsulatum and Others Fungal Pathogens
Published on: February 14, 2011
Monoclonal antibody to fungal glucosylceramide protects mice against lethal Cryptococcus neoformans infection
Marcio L Rodrigues1, Li Shi, Eliana Barreto-Bergter
1Instituto de Microbiologia Professor Paulo de Góes, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-590, Brazil. marcio@micro.ufrj.br
Clinical and Vaccine Immunology : CVI
|August 24, 2007
Abstract:
Glucosylceramides (GlcCer) are involved in the regulation of Cryptococcus neoformans virulence. In the present study, we demonstrate that passive immunization with a monoclonal antibody to GlcCer significantly reduces host inflammation and prolongs the survival of mice lethally infected with C. neoformans, revealing a potential therapeutic strategy to control cryptococcosis.

