[Thrombotic reactions of vascular anastomoses: comparison of model studies with experimental findings]

The areas of predilection for atherosclerosis and thrombosis in the vascular system are characterized by curvature, branching, bifurcation or embankment. We have investigated induced thrombus formation at arteriolar bifurcations with migrating stagnation points and local vortex flow. Thrombogenic endothelial lesions were produced in rat mesenteric arterioles by argon laser injury or by photochemical reactions (using FITC-dextran 70). The following items have been evaluated: local red blood cell velocity, geometry of the vessel, localization of the first thrombus growth. The first appearance of thrombus formation at presumably (re-) attachment points at bifurcations in the microcirculation could be directly demonstrated by intravital microscopy.