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Published on: November 12, 2021
Callophycoic acids and callophycols from the Fijian red alga Callophycus serratus
Amy L Lane1, Elizabeth P Stout, Mark E Hay
1School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, GA 30332, USA.
Abstract:
Callophycoic acids A-H (1-8) and callophycols A and B (9 and 10) were isolated from extracts of the Fijian red alga Callophycus serratus, and identified by NMR, X-ray, and mass spectral analyses. These natural products represent four novel carbon skeletons, providing the first examples of diterpene-benzoic acids and diterpene-phenols in macroalgae. Compounds 1-10 exhibited antibacterial, antimalarial, and anticancer activity, although they are less bioactive than diterpene-benzoate macrolides previously isolated from this red alga.
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