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Related Experiment Video

Updated: Jul 12, 2026

A Label-free Technique for the Spatio-temporal Imaging of Single Cell Secretions

A Label-free Technique for the Spatio-temporal Imaging of Single Cell Secretions

Published on: November 23, 2015

Localized surface plasmon resonance biosensors.

Jing Zhao¹, Xiaoyu Zhang, Chanda Ranjit Yonzon

¹Northwestern University, Department of Chemistry, Evanston, IL 60208-3113, USA.

Nanomedicine (London, England)

|August 25, 2007

Summary

This summary is machine-generated.

Noble metal nano-optical sensors utilizing localized surface plasmon resonance (LSPR) show promise for detecting biomarkers like amyloid-derived diffusable ligands. This review highlights advancements in LSPR sensor development and applications.

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Real Time Measurements of Membrane Protein:Receptor Interactions Using Surface Plasmon Resonance (SPR)

Real Time Measurements of Membrane Protein:Receptor Interactions Using Surface Plasmon Resonance (SPR)

Published on: November 29, 2014

Area of Science:

Nanotechnology
Spectroscopy
Biomedical Sensing

Background:

Localized Surface Plasmon Resonance (LSPR) spectroscopy is a powerful technique for developing nano-optical sensors.
LSPR sensors detect changes in their local dielectric environment caused by binding events, leading to spectral shifts.
Noble metal nanoparticles serve as effective platforms for LSPR-based sensing applications.

Purpose of the Study:

To summarize recent advancements in noble metal nano-optical sensors based on LSPR spectroscopy.
To highlight the fabrication of LSPR sensing platforms using nanosphere lithography.
To showcase biosensing applications, including Alzheimer's disease biomarker detection.

Main Methods:

Utilizing nanosphere lithography for cost-effective fabrication of nanoparticle sensing platforms.
Employing LSPR spectral shifts to detect changes in the surrounding dielectric environment.
Developing modified LSPR sensing methods for diverse applications.

Main Results:

Demonstrated LSPR detection of amyloid-derived diffusable ligands, a biomarker for Alzheimer's disease, in biological samples.
Presented a multiplex sensing LSPR chip.
Introduced a combined electrochemical and LSPR protocol.
Described a fabrication method for solution-phase nanotriangles.

Conclusions:

Noble metal nano-optical sensors based on LSPR spectroscopy offer a versatile platform for various sensing applications.
LSPR technology, particularly when fabricated with nanosphere lithography, provides a sensitive and adaptable method for biosensing.
Further modifications and combinations with other techniques enhance the utility of LSPR sensors for complex detection challenges.