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Combined Near-infrared Fluorescent Imaging and Micro-computed Tomography for Directly Visualizing Cerebral Thromboemboli

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Published on: September 25, 2016

Fibrin-targeted perfluorocarbon nanoparticles for targeted thrombolysis.

J N Marsh¹, A Senpan, G Hu

¹Washington University School of Medicine, Cardiovascular Division, St Louis, MO 63108, USA. jnm@cvu.wustl.edu

Nanomedicine (London, England)

|August 25, 2007

Summary

Researchers developed targeted nanoparticles to deliver streptokinase for rapid clot dissolution in stroke. This novel approach shows promise for effective and safer thrombolysis in acute ischemic stroke treatment.

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A Fibrin-Enriched and tPA-Sensitive Photothrombotic Stroke Model

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Published on: June 4, 2021

Area of Science:

Biomedical Engineering
Nanotechnology
Cardiovascular Research

Background:

Reperfusion therapy is crucial for acute stroke, but current treatments like recombinant tissue plasminogen activator have limitations.
Hemorrhagic complications restrict thrombolytic use, necessitating targeted approaches for improved safety and efficacy.

Purpose of the Study:

To develop fibrin-specific, perfluorocarbon nanoparticles for targeted delivery of streptokinase.
To evaluate the in vitro effectiveness of these nanoparticles for targeted thrombolysis using acoustic microscopy.

Main Methods:

In vitro human plasma clots were treated with streptokinase-loaded nanoparticles, control nanoparticles, or a combination.
Quantitative acoustic microscopy was used to monitor clot morphology and backscatter changes over 1 hour.
Clots were exposed to phosphate-buffered saline (PBS) with or without plasminogen and free streptokinase.

Main Results:

Streptokinase-loaded nanoparticles significantly enhanced acoustic contrast, enabling volumetric clot estimation.
Targeted nanoparticles rapidly induced fibrinolysis (<60 min) in the presence of plasminogen without adverse effects.
Targeted streptokinase required significantly lower concentrations for effective clot lysis compared to free streptokinase.

Conclusions:

A novel nanoparticle-based agent demonstrated specific and rapid in vitro fibrinolysis.
This targeted thrombolytic approach holds potential for clinical application in acute ischemic stroke reperfusion therapy.