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Related Experiment Video

Updated: Jul 12, 2026

Core/shell Printing Scaffolds For Tissue Engineering Of Tubular Structures

Core/shell Printing Scaffolds For Tissue Engineering Of Tubular Structures

Published on: September 27, 2019

Aligned core-shell nanofibers delivering bioactive proteins.

I C Liao¹, S Y Chew, K W Leong

¹Department of Biomedical Engineering, Duke University, Durham, NC 27708, USA.

Nanomedicine (London, England)

|August 25, 2007

Summary

This study demonstrates co-axial electrospinning for creating protein-releasing nanofibers for tissue engineering. Poly(ethylene glycol) controls release, enabling sustained delivery of growth factors for regenerative medicine.

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Area of Science:

Biomaterials Science
Tissue Engineering
Regenerative Medicine

Background:

Continuous nanostructures can deliver topographical and biochemical cues for tissue regeneration.
Co-axial electrospinning offers a method to embed proteins within nanofibers.

Purpose of the Study:

To develop aligned nanofibers using co-axial electrospinning encapsulating bovine serum albumin (BSA) and platelet-derived growth factor-bb (PDGF-bb).
To demonstrate controlled release of BSA and bioactivity retention of PDGF-bb.
To explore applications in regenerative medicine.

Main Methods:

Co-axial electrospinning of poly(epsilon-caprolactone) (PCL) nanofibers.
Incorporation of poly(ethylene glycol) (PEG) as a porogen in the PCL shell for controlled release.
Encapsulation of BSA and PDGF-bb within the nanofibers.

Main Results:

BSA release half-lives ranged from 1 to 20 days, dependent on PEG concentration and molecular weight.
Optimized PDGF-bb-loaded nanofibers achieved complete release with near zero-order kinetics.
Preserved bioactivity of PDGF-bb was confirmed.

Conclusions:

Co-axial electrospinning is a versatile technique for controlled delivery of biochemical signals.
This approach holds promise for tissue engineering and regenerative medicine applications.