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In Vivo Modeling of the Morbid Human Genome using Danio rerio
Published on: August 24, 2013
Characterization of the drugged human genome
Martin Lauss1, Albert Kriegner, Klemens Vierlinger
1Austrian Research Centers, Molecular Diagnostics, A-2444 Seibersdorf, Austria. martin.lauss@arcs.ac.at
Pharmacogenomics
|August 25, 2007
Summary
Human drug targets, primarily rhodopsin-like receptors, are concentrated in specific pathways and tissues. Further analysis explores their overlap with genes linked to Mendelian disorders and cancer.
Area of Science:
- Genomics
- Pharmacology
- Biochemistry
Background:
- Human drug targets are crucial for understanding and treating diseases.
- The complete profile of drug target genes, including their characteristics and distribution, remains incompletely understood.
Purpose of the Study:
- To comprehensively analyze the characteristics and distribution of known human drug targets.
- To compare drug target genes with the broader human genome to identify unique features.
- To investigate the potential for drug targets in treating diverse disease classes.
Main Methods:
- Utilized the DrugBank database to collect 392 human drug targets.
- Analyzed gene involvement in biochemical functions, biological processes, and pathways.
- Assessed chromosome, cellular, and tissue distribution of drug target genes.
- Compared drug target gene characteristics with the entire human genome.
Main Results:
- Human drug targets exhibit limited diversity, with a significant prevalence of rhodopsin-like 7 transmembrane receptors.
- These targets are predominantly involved in the neuroactive ligand-receptor interaction pathway and located in the plasma membrane.
- Drug target genes are frequently expressed across multiple tissues, indicating potential for broad therapeutic applications.
- Identified intersections between drug targets and genes associated with Mendelian disorders and cancer signatures.
Conclusions:
- The current landscape of human drug targets is characterized by a specific subset of genes, notably transmembrane receptors.
- The widespread tissue expression of drug targets suggests potential for treating various diseases.
- Understanding these characteristics provides insights into drug discovery and development strategies.
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