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Related Experiment Videos

Reported methodological quality of split-mouth studies.

Emmanuel Lesaffre1, Maria-José Garcia Zattera, Carol Redmond

  • 1Biostatistical Centre, Catholic University Leuven, Leuven, Belgium. emmanuel.lesaffre@med.kuleuven.be

Journal of Clinical Periodontology
|August 25, 2007
PubMed
Summary
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This review found that many split-mouth dental studies in 2004 lacked essential methodological reporting. Improvements are needed in study design rationale, statistical analysis, and sample size calculations for split-mouth clinical trials.

Area of Science:

  • Dental research methodology
  • Clinical trial design

Background:

  • Previous work questioned the quality of split-mouth studies.
  • Limited subsequent investigation into split-mouth study methodology occurred.
  • This study systematically reviewed split-mouth clinical trials from 2004.

Purpose of the Study:

  • To systematically review the reported methodology of split-mouth clinical studies.
  • To assess the quality of reporting in dental journals.
  • To identify areas for improvement in split-mouth study design and analysis.

Main Methods:

  • A systematic review of split-mouth studies published in 2004.
  • Utilized an extension of CONSORT guidelines for cluster-randomized designs for quality evaluation.
  • Assessed methods and reporting quality of included studies.

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Main Results:

  • Thirty-four split-mouth studies were included.
  • Many studies lacked essential reporting qualities.
  • Few studies provided rationale for design (5/34), used appropriate statistics (19/34), or sample size calculations (1/34).
  • None of the five studies using survival analysis employed a paired approach.

Conclusions:

  • Despite statistical analysis advancements, reporting quality remains a concern.
  • Key aspects of split-mouth study design and analysis require further development.
  • Improved reporting is crucial to reflect actual trial methodology accurately.