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Treatment of pathologic laughing and crying
Hal S Wortzel1, C Alan Anderson, David B Arciniegas
1David B. Arciniegas, MD Brain Injury Rehabilitation Unit, HealthONE Spalding Rehabilitation Hospital, Aurora, CO 80011, USA. david.arciniegas@uchsc.edu.
Current Treatment Options in Neurology
|August 25, 2007
Summary
Pathologic laughing and crying (PLC) involves uncontrollable emotional outbursts due to neurological conditions. Selective serotonin reuptake inhibitors (SSRIs) are effective first-line treatments for managing these symptoms.
Area of Science:
- Neurology
- Psychiatry
Background:
- Pathologic laughing and crying (PLC) are involuntary emotional outbursts linked to neurological disorders.
- These episodes can be disproportionate to stimuli and may not align with the patient's internal feelings.
Purpose of the Study:
- To define Pathologic laughing and crying (PLC) and differentiate it from mood disorders.
- To outline diagnostic and therapeutic strategies for PLC.
Main Methods:
- Literature review of neurologic and psychiatric conditions associated with PLC.
- Analysis of treatment efficacy for various pharmacologic interventions.
Main Results:
- PLC is distinct from depression or mania, characterized by uncontrollable affect episodes.
- Selective serotonin reuptake inhibitors (SSRIs) are recommended as first-line treatments.
- Alternative treatments include tricyclic antidepressants and dextromethorphan/quinidine.
Conclusions:
- Prompt neurological evaluation is crucial when PLC is a presenting symptom.
- SSRIs offer a safe and effective treatment for PLC.
- Supportive therapy aids in managing social and emotional challenges associated with PLC.
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