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Chronic Thromboembolic Pulmonary Hypertension and Assessment of Right Ventricular Function in the Piglet
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Correlation between cardiac biomarkers and right ventricular enlargement on chest CT in non massive pulmonary

Nicolas Vuilleumier1, Marc Righini, Arnaud Perrier

  • 1Department of Pathology, Clinical Chemistry, Geneva University Hospital, Switzerland. nicolas.vuilleumier@hcuge.ch

Thrombosis Research
|August 25, 2007
PubMed

Insights

Natriuretic peptides are significantly elevated in patients with pulmonary embolism (PE) and right ventricular dysfunction (RVD). These peptides correlate with RVD severity, unlike other cardiac biomarkers.

Area of Science:

  • Cardiology
  • Pulmonary Medicine
  • Biomarker Research

Background:

  • Pulmonary embolism (PE) is associated with elevated cardiac biomarkers including troponin I, myoglobin, H-FABP, and natriuretic peptides.
  • Right ventricular dysfunction (RVD) is a critical complication in PE.

Purpose of the Study:

  • To investigate the correlation between cardiac biomarkers and helical computed tomography (hCT) assessed RVD in non-massive PE patients.
  • To compare the diagnostic utility of natriuretic peptides versus cardiomyocyte damage markers in identifying RVD.

Main Methods:

  • Prospective pilot study involving 50 patients with non-massive PE.
  • Assessment of troponin I, myoglobin, H-FABP, BNP, and NT-proBNP levels.
  • Correlation analysis with hCT-derived right ventricular dysfunction (RVD) and RV/LV index.

Main Results:

  • Natriuretic peptides showed significantly higher prevalence and median plasma values in patients with RVD compared to those without.
  • BNP and NT-proBNP levels were significantly higher in patients with RVD.
  • Significant correlations were found between the RV/LV index and plasma levels of NT-proBNP and BNP.

Conclusions:

  • Elevated natriuretic peptides (BNP, NT-proBNP) are significantly associated with the presence and severity of RVD in non-massive PE.
  • Natriuretic peptides demonstrate greater diagnostic value for RVD in PE than cardiomyocyte damage markers.
Abstract

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