Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Nephrogenic systemic fibrosis].

W Samtleben1

  • 1Schwerpunkt Nephrologie, Medizinische Klinik und Poliklinik I, Klinikum Grosshadern der Ludwig-Maximilians-Universität München, Marchioninistrasse 15, 81377 München, Deutschland. walter.samtleben@med.uni-muenchen.de

Der Radiologe
|August 25, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Acute postinfectious glomerulonephritis associated with Campylobacter jejuni enteritis - a case report and review of the literature on C. jejuni's potential to trigger immunologically mediated renal disease.

Clinical nephrology·2010
Same author

Fibrillary glomerulonephritis mimicking membranous nephropathy--a diagnostic pitfall.

Pathology, research and practice·2009
Same author

[Orellanus syndrome: a rare cause of acute renal failure].

Deutsche medizinische Wochenschrift (1946)·2007
Same author

Comparative evaluation of oxidative and antioxidative capacity during high-flux hemodialysis using two different membranes.

Clinical nephrology·2006
Same author

Resistance to intercompartmental mass transfer limits beta2-microglobulin removal by post-dilution hemodiafiltration.

Kidney international·2006
Same author

Functional magnetic resonance imaging in renal artery stenosis.

Abdominal imaging·2005
Same journal

Der Radiologe·2024
Same journal

Der Radiologe·2024
Same journal

Der Radiologe·2024
Same journal

Der Radiologe·2024
Same journal

Der Radiologe·2022
Same journal

Der Radiologe·2022
See all related articles

Nephrogenic systemic fibrosis (NSF) is a severe skin disorder linked to gadolinium contrast agents used in MRI scans. Patients with severe kidney insufficiency (GFR <30) are at high risk and should avoid these contrast-enhanced scans.

Area of Science:

  • Nephrology
  • Radiology
  • Dermatology

Background:

  • Nephrogenic systemic fibrosis (NSF) is a rare, severe condition.
  • First described in 1997 and termed nephrogenic fibrosing dermopathy in 2000.
  • Linked to gadolinium-based contrast agents (GBCAs) in MRI scans since 2006.

Purpose of the Study:

  • To review the clinical presentation, risk factors, and management of NSF.
  • To highlight the association between GBCAs and NSF in patients with renal impairment.
  • To recommend avoiding contrast-enhanced MRI in at-risk populations.

Main Methods:

  • Review of reported cases and international registries.
  • Analysis of patient history, particularly preceding contrast-enhanced MRI.
  • Assessment of renal function, specifically glomerular filtration rate (GFR).

Related Experiment Videos

Main Results:

  • NSF affects skin, muscles, and potentially other organs, causing progressive fibrosis and contractures.
  • Approximately 215 cases reported, with a mortality rate up to 28%.
  • High-risk patients have GFR <30 ml/min per 1.73 m(2) or hepatorenal dysfunction.

Conclusions:

  • Contrast-enhanced MRI with GBCAs should be avoided in patients with severe renal insufficiency.
  • Alternative diagnostic methods are recommended for at-risk individuals.
  • Pathogenesis remains unclear, but gadolinium release is a leading hypothesis.