Related Experiment Video
Updated: Jul 12, 2026

A Step by Step Protocol for Subretinal Surgery in Rabbits
Published on: September 13, 2016
[Traumatic submacular hemorrhage treated with rt-PA and SF6]
H Heras-Mulero1, P J García-Gómez, L M Sádaba-Echarri
1Departamento de Oftalmología, Clínica Universitaria de Navarra, Pamplona (Navarra), España. henarheras@yahoo.es
Case Report:
This patient was afflicted by a traumatic submacular hemorrhage. A posterior vitrectomy was performed and intravitreal rt-PA and SF6 were administered. Four weeks later, the visual acuity had increased from 0.1 to 0.8. No complications due to the treatment with rt-PA were reported.
Discussion:
It is known that waiting for the spontaneous blood removal in such cases results in a poor visual acuity recovery due to a toxic effect of the blood products. Both rt-PA and the SF6 are useful for the treatment of submacular hemorrhages secondary to age-related macular degeneration, and this case report has shown they are also useful to lyse traumatic blood clots, thus contributing to a better recovery of visual acuity.
