Related Experiment Video
Updated: Jul 12, 2026

An Experimental Model to Study Tuberculosis-Malaria Coinfection upon Natural Transmission of Mycobacterium tuberculosis and Plasmodium berghei
Published on: February 17, 2014
[Impact of M. tuberculosis genotype on survival in mice with experimental tuberculosis]
Abstract:
To study the virulence of Mycobacterium tuberculosis strains of the W cluster, C57B1/6 mice were intravenously inoculated with a lethal dose (5x10(6) CFU) of 14 clinical M. tuberculosis strains (11 drug-sensitive and 3 multidrug-resistant) belonging to different RFDP IS6110 genotypic clusters and two laboratory M. tuberculosis strains H37Rv and H37Ra. The virulence was evaluated by the survival of mice after infection and by the trends in body weight loss. The study indicated that the mice inoculated with different M. tuberculosis strains differed in survival rates and in the trend in body weight loss. A minor HD cluster strain and 2 non-clustered strains were most virulent, next were 2 AI cluster strains. W cluster strains had both higher (n = 2) and lower (n = 3), and comparable (n = 2) H37Rv virulence. A KQ cluster strain had the least virulence. An attenuated H37Ra strain caused no animal death. Inoculation with three multidrug-resistant strains belonging to the W cluster (n = 2) and one non-clustered strain demonstrated no relationship of virulence to the sensitivity of a strain to antituberculous agents. The findings argue against the opinion on W cluster M. tuberculosis strains as hypervirulent.
Related Concept Videos
Tuberculosis
Pulmonary Tuberculosis II
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
Pulmonary Tuberculosis IV
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
Pulmonary Tuberculosis III
The first classification is based on the development of the disease, and it includes the following categories:
Pulmonary Tuberculosis I
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
