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[Multicenter study with gliquidone in type 2 diabetes mellitus].

A Kreze¹, J Vozár, P Rázus

¹Endokrinologický ústav, Lubochna.

Vnitrni Lekarstvi

|September 1, 1991

Summary

Gliquidone, a new sulfonylurea, effectively treats type 2 diabetes with good tolerance. This antidiabetic medication showed minimal side effects and did not worsen kidney or liver function in patients with complications.

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Area of Science:

Endocrinology
Pharmacology
Internal Medicine

Background:

Type 2 diabetes mellitus (T2DM) is a growing global health concern.
Effective and well-tolerated oral antidiabetic agents are crucial for T2DM management.
Sulfonylureas are a common class of oral hypoglycemic agents.

Purpose of the Study:

To evaluate the efficacy and tolerance of gliquidone, a new sulfonylurea.
To assess the safety profile of gliquidone in patients with type 2 diabetes.
To investigate the impact of gliquidone on renal and hepatic function in specific patient subgroups.

Main Methods:

A three-month clinical trial involving 39 patients with type 2 diabetes.
Administration of gliquidone (Glurenorm) as the primary intervention.

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Monitoring of glycemic control, side effects, and specific biochemical markers.

Main Results:

Gliquidone demonstrated medium-strength beta-cytotropic antidiabetic activity.
Only one patient (2.5%) experienced dyspepsia; no symptomatic hypoglycemia occurred.
Renal function indicators remained stable in patients with diabetic nephropathy.
Elevated gamma-glutamyl transpeptidase levels normalized in patients with concurrent hepatopathy.

Conclusions:

Gliquidone is an effective and well-tolerated antidiabetic agent for type 2 diabetes.
The drug is safe for patients with type 2 diabetes, even those with associated nephropathy or hepatopathy.
Gliquidone presents a favorable option for managing type 2 diabetes, including in patients with comorbidities.