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Updated: Jul 12, 2026

Symptom Assessment of Patients with Allergic Rhinitis Using an Allergen Exposure Chamber
Published on: March 3, 2023
Aeroallergen sensitization rates in military children with rhinitis symptoms
Christopher W Calabria1, John Dice
1Department of Allergy and Immunology, Wilford Hall Medical Center, Lackland AFB, Texas 78236, USA. christopher.calabria@lackland.af.mil
Insights
Childhood aeroallergen sensitization is common and increases with age. Perennial allergens are most prevalent in young children, with rates for many allergens underreported in previous studies.
Area of Science:
- Pediatric Allergy and Immunology
- Environmental Health
- Immunology
Background:
- Childhood sensitization rates to common aeroallergens are frequently underestimated.
- Rhinitis is a common condition in children, often linked to environmental allergens.
Purpose of the Study:
- To determine aeroallergen sensitization prevalence in military children with rhinitis.
- To analyze the age-related development of atopy to perennial and seasonal allergens.
Main Methods:
- Retrospective analysis of a skin testing database for children aged 18 and younger.
- Skin prick testing performed using either an 8-test screening panel or a comprehensive 51-allergen panel.
Main Results:
- 35.4% of children tested with the 8-test panel had positive results; atopy increased significantly with age.
- With the 51-allergen panel, 80.3% of children showed at least one positive result, averaging 11.4 positive tests.
- Common allergens included mold, cat, dust mite, grasses, and trees; perennial allergens predominated in younger children.
Conclusions:
- Aeroallergen sensitization is highly prevalent in children and escalates with age.
- Perennial allergens are the primary sensitizers in children under three years old.
- The study provides data on underreported allergens, applicable beyond a military population.
Background:
Childhood sensitization rates for many aeroallergens are underreported.
Objectives:
To examine aeroallergen sensitization rates in military children undergoing skin testing for rhinitis and investigate the timing of atopic development for perennial and seasonal allergens.
Methods:
A skin testing database was retrospectively analyzed. Children 18 years and younger referred for rhinitis underwent skin prick testing to either a screening panel of 8 tests or a standard panel of 51 allergens.
Results:
A total of 209 patients underwent skin testing to the 8-test panel. Of these patients, 35.4% had at least 1 positive result. Atopy increased with age, from 6.3% in those younger than 1 year to 58.8% in those 5 years old. The most common allergens were mold mix (16.3%), cat (13.2%), dust mite mix (11.4%), tree mix (9.4%), and grass mix (9.4%). Only 4.0% were sensitized to seasonal aeroallergens before the age of 3 years. A total of 345 children underwent testing to a 51-allergen panel. A total of 80.3% had at least 1 positive test result, and the average number of positive test results was 11.4. Both the percentage of atopy and the average number of positive skin test results increased with age. The most common allergens were grasses, Alternaria, and cottonwood. Thirty-two of 51 allergens were positive in 20% or more children. Rates for many underreported allergens are presented.
Conclusions:
In children, aeroallergen sensitization rates are high and increase with age. Perennial allergens predominate up to the age of 3 years. Rates for many underreported allergens are presented. Although performed in a military population, these results should be applicable to many practices.
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