Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Method for microbubble characterization using primary radiation force.

Hendrik J Vos1, Francesco Guidi, Enrico Boni

  • 1Department of Electronics and Telecommunications, University of Florence, Florence, Italy.

IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
|August 28, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Ultrafast ultrasound shear wave elastography: a novel approach for assessing myocardial stiffening in congenital aortic stenosis.

Open heart·2026
Same author

Left Ventricular Strain-Volume Loops in a Healthy Population: The Role of Sex and Age.

Echocardiography (Mount Kisco, N.Y.)·2026
Same author

Correction: Continuous shear wave measurements for dynamic cardiac stiffness evaluation in pigs.

Scientific reports·2026
Same author

Extremely Large-Aperture Arrays for V2X Communication, Localization and Sensing.

Sensors (Basel, Switzerland)·2026
Same author

Dynamic mode decomposition as a framework for denoising ultrafast power doppler images.

Computer methods and programs in biomedicine·2025
Same author

Dual-mode mid-infrared plasmonic metasurface for real-time label-free analysis of live cells.

Talanta·2025
Same journal

Theoretical Foundations of the Echo Envelope Statistical Modeling: A Tutorial.

IEEE transactions on ultrasonics, ferroelectrics, and frequency control·2025
Same journal

Practical Demonstrations of FR3-Band Thin-Film Lithium Niobate Acoustic Filter Design.

IEEE transactions on ultrasonics, ferroelectrics, and frequency control·2025
Same journal

Real-Time Heterogeneous Helical Wave Spectrum Method for Transabdominal Passive Acoustic Mapping.

IEEE transactions on ultrasonics, ferroelectrics, and frequency control·2025
Same journal

Cascaded Plane Wave Ultrasound Velocity Vector Imaging: In Vivo Feasibility in Carotid Arteries.

IEEE transactions on ultrasonics, ferroelectrics, and frequency control·2025
Same journal

Quantitative Acoustic Attenuation Scanning Using a Phase-Insensitive Ultrasound Computed Tomography System.

IEEE transactions on ultrasonics, ferroelectrics, and frequency control·2025
Same journal

FPGA-Accelerated CNN Reconstruction for Low-Power Sparse-Array Ultrasound Imaging.

IEEE transactions on ultrasonics, ferroelectrics, and frequency control·2025
See all related articles

This study characterizes ultrasound contrast agent (UCA) bubbles by measuring their movement under ultrasound radiation force. Researchers developed a new method to determine the viscoelastic properties of UCA shells, advancing their use in medical imaging and drug delivery.

Area of Science:

  • Biomedical Engineering
  • Acoustic Physics
  • Materials Science

Background:

  • Ultrasound contrast agents (UCAs) are evolving beyond simple imaging enhancers to become sophisticated tools for diagnostics and therapeutics.
  • The precise dynamic behavior of encapsulated bubbles within UCAs remains incompletely understood, limiting their full potential.
  • Understanding bubble dynamics is crucial for optimizing UCA performance in medical applications.

Purpose of the Study:

  • To characterize the dynamic behavior of individual bubbles within ultrasound contrast agents (UCAs).
  • To investigate the influence of bubble physical dimensions and encapsulation viscoelastic properties on UCA translational motion.
  • To develop and validate a novel method for estimating the viscoelastic properties of UCA encapsulation.

Main Methods:

Related Experiment Videos

  • Utilized a programmable ultrasound transmitter/receiver setup with novel real-time display modes.
  • Measured bubble displacements induced by ultrasound radiation force at 2-8 MHz frequencies and 150 kPa to 1.5 MPa pressures.
  • Employed a numerical model based on the modified Herring equation and Bjerknes force to simulate bubble velocities for parameter fitting.

Main Results:

  • Successfully observed and analyzed the translational motion of individual UCA bubbles.
  • Demonstrated that bubble behavior is dependent on physical size and the viscoelasticity of the encapsulation material.
  • Quantified viscoelastic properties: PVC-AN shell (shear modulus 18 MPa, viscosity 0.23 Pas) and phospholipid shell (elasticity 0.8 N/m, friction 1x10^-7 kg/s).

Conclusions:

  • The developed method accurately estimates the viscoelastic properties of UCA bubble shells.
  • Findings provide critical insights into UCA bubble dynamics, essential for advancing their application in medical imaging and drug delivery.
  • This research contributes to the precise characterization of UCAs, paving the way for improved diagnostic and therapeutic strategies.