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Updated: Jul 12, 2026

Efficient Synthesis of Polyfunctionalized Benzenes in Water via Persulfate-promoted Benzannulation of α,β-Unsaturated Compounds and Alkynes
Published on: December 16, 2019
A practical and general synthesis of unsymmetrical terphenyls
Jose M Antelo Miguez1, Luis Angel Adrio, Antonio Sousa-Pedrares
1Departamento de Química InorgAnica, Facultad de Química, Universidad de Santiago de Compostela, E-15782, Spain.
Abstract:
A synthetic procedure was developed that enables sequential chemoselective Suzuki-Miyaura cross-coupling of chlorobromobenzene with arylboronic acids. The first coupling is achieved at room temperature using a ligandless palladium catalyst. The chlorobiaryl product can then be subjected directly to the second coupling, facilitated by the SPhos ligand. Using this methodology, parallel synthesis of 32 unsymmetrical o-, m-, and p-terphenyl compounds was accomplished in good to excellent overall yields.
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